Preclinical Study of a Biparatopic METxMET Antibody-Drug Conjugate, REGN5093-M114, Overcomes MET-driven Acquired Resistance to EGFR TKIs in EGFR-mutant NSCLC

Oh, SY; Lee, YW; Lee, EJ; Kim, JH; Park, Y; Heo, SG; Yu, MR; Hong, MH; DaSilva, J; Daly, C; Cho, BC; Lim, SM; Yun, MR

Lim, SM; Yun, MR (通讯作者),Yonsei Univ, Coll Med, Yonsei Canc Ctr, Div Med Oncol, 50 Yonsei Ro, Seoul 120752, South Korea.

CLINICAL CANCER RESEARCH, 2023; 29 (1): 221

Abstract

Purpose: MET amplification is a frequent mechanism of resistance to EGFR tyrosine kinase inhibitors (TKI) in patients with EGFR-mutated non-small cell......

Full Text Link