Preliminary SAR and biological evaluation of potent HIV-1 protease inhibitors with pyrimidine bases as novel P2 ligands to enhance activity against DRV-resistant HIV-1 variants

Zhu, M; Ma, L; Zhou, HY; Dong, B; Wang, YJ; Wang, Z; Zhou, JM; Zhang, GN; Wang, JX; Liang, C; Cen, S; Wang, YC

Cen, S; Wang, YC (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020; 185 ():

Abstract

Introducing pyrimidine bases, the basic components of nucleic acid, to P2 ligands might enhance the potency of Human Immunodeficiency Virus-1 (HIV-1) ......

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