Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein

Dong, D; Guo, MH; Wang, SH; Zhu, YW; Wang, S; Xiong, Z; Yang, JZ; Xu, ZL; Huang, ZW

Huang, ZW (reprint author), Harbin Inst Technol, Sch Life Sci & Technol, HIT Ctr Life Sci, Harbin 150080, Peoples R China.

NATURE, 2017; 546 (7658): 436

Abstract

CRISPR-Cas9 systems are bacterial adaptive immune systems that defend against infection by phages. Through the RNA-guided endonuclease activity of Cas......

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