5-Methyl-N-(8-(5,6,7,8-tetrahydroacridin-9-ylamino) octyl)-5H-indolo[2,3-b] quinolin-11-amine: a highly potent human cholinesterase inhibitor

Wang, L; Moraleda, I; Iriepa, I; Romero, A; Lopez-Munoz, F; Chioua, M; Inokuchi, T; Bartolini, M; Marco-Contelles, J

Inokuchi, T (reprint author), Okayama Univ, Grad Sch Nat Sci & Technol, Div Chem & Biotechnol, Kita Ku, 3-1-1 Tsushima Naka, Okayama 7008530, Japan.; Marco-Contelles, J (reprint author), CSIC, Lab Med Chem IQOG, C Juan de la Cierva 3, Madrid 28006, Spain.

MEDCHEMCOMM, 2017; 8 (6): 1307

Abstract

The synthesis, cholinesterase inhibition, molecular modelling and ADME properties of novel tacrineneocryptolepine heterodimers are described. Compound......

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