Bidirectional pharmacokinetic drug interactions between olaparib and metformin

Stanislawiak-Rudowicz, J; Karbownik, A; Szkutnik-Fiedler, D; Otto, F; Grabowski, T; Wolc, A; Grzeskowiak, E; Szalek, E

Stanislawiak-Rudowicz, J (通讯作者)，Poznan Univ Med Sci, Dept Clin Pharm & Biopharm, Rokietnicka 3, PL-60806 Poznan, Poland.;Stanislawiak-Rudowicz, J (通讯作者)，Poznan Univ Clin Hosp, Szamarzewskiego 84-86, PL-60569 Poznan, Poland.

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2023; ():

Abstract

ObjectiveOlaparib is a PARP (poly-ADP-ribose polymerase) inhibitor used for maintenance therapy in BRCA-mutated cancers. Metformin is a first-choice d......

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