Dual targeting of lymphocyte homing and retention through alpha 4 beta 37 and alpha E beta 7 inhibition in inflammatory bowel disease

Dai, BB; Hackney, JA; Ichikawa, R; Nguyen, A; Elstrott, J; Orozco, LD; Sun, KH; Modrusan, Z; Gogineni, A; Scherl, A; Gubatan, J; Habtezion, A; Deswal, M; Somsouk, M; Faubion, WA; Chai, A; Sharafali, Z; Hassanali, A; Oh, YS; Tole, S; McBride, J; Keir, ME; Yi, TS

Yi, TS (corresponding author), Genentech Inc, Dept Immunol Discovery, 1 DNA Way, San Francisco, CA 94080 USA.; Keir, ME (corresponding author), Genentech Inc, Biomarker Discovery OMNI, 1 DNA Way, San Francisco, CA 94080 USA.

CELL REPORTS MEDICINE, 2021; 2 (8):

Abstract

Anti-integrins are therapeutically effective for inflammatory bowel disease, yet the relative contribution of alpha 4 beta 7 and alpha E beta 7 to gut......

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