ONC201 Shows Potent Anticancer Activity Against Medullary Thyroid Cancer via Transcriptional Inhibition of RET, VEGFR2, and IGFBP2

Bagheri-Yarmand, R; Dadu, R; Ye, L; Jebaraj, YS; Martinez, JA; Ma, JS; Tarapore, RS; Allen, JE; Sherman, SI; Williams, MD; Gagel, RF

Bagheri-Yarmand, R (corresponding author), Univ Texas MD Anderson Canc Ctr, 6565 Anderson Blvd, Houston, TX 77030 USA.

MOLECULAR CANCER THERAPEUTICS, 2021; 20 (4): 665

Abstract

Gain-of-function point mutations in the receptor tyrosine kinase RET, a driver oncogene in medullary thyroid carcinoma (MTC), prevent apoptosis throug......

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