KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RAR alpha

Wang, XR; Fan, HY; Xu, CL; Jiang, GJ; Wang, HW; Zhang, J

Zhang, J (reprint author), Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, State Key Lab Med Genom,Shanghai Inst Hematol, Shanghai 200025, Peoples R China.; Wang, HW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Shanghai 20002

CANCER CELL INTERNATIONAL, 2019; 19 (1):

Abstract

Background A hallmark of acute promyelocytic leukemia (APL) is the expression of PML/RAR alpha fusion protein. Treatment with all-trans retinoic acid ......

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