Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib

Goroshchuk, O; Kolosenko, I; Kunold, E; Vidarsdottir, L; Pirmoradian, M; Azimi, A; Jafari, R; Palm-Apergi, C

Jafari, R (corresponding author), Karolinska Inst, Sci Life Lab, Clin Prote Mass Spectrometry, Dept Oncol Pathol, Tomtebodavagen 23A, S-17165 Solna, Sweden.; Palm-Apergi, C (corresponding author), Karolinska Inst, Dept Lab Med Biomol & Cellular Med, Halsovagen 7, S-14157 Huddinge, Sweden.; Palm-Apergi, C (corresponding author), Karolinska Univ Hosp, Huddinge, Sweden.

FASEB JOURNAL, 2021; 35 (7):

Abstract

Polo-like kinase 1 (PLK1) is an important cell cycle kinase and an attractive target for anticancer treatments. An ATP-competitive small molecular PLK......

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