Nanoparticles Displaying Allergen and Siglec-8 Ligands Suppress IgE-Fc epsilon RI-Mediated Anaphylaxis and Desensitize Mast Cells to Subsequent Antigen Challenge

Duan, ST; Arlian, BM; Nycholat, CM; Wei, YD; Tateno, H; Smith, SA; Macauley, MS; Zhu, Z; Bochner, BS; Paulson, JC

Paulson, JC (corresponding author), Scripps Res Inst, 10550 North Torrey Pines Rd,MB-202, La Jolla, CA 92037 USA.

JOURNAL OF IMMUNOLOGY, 2021; 206 (10): 2290

Abstract

Siglec-8 is an inhibitory receptor expressed on eosinophils and mast cells. In this study, we took advantage of a novel Siglec-8 transgenic mouse mode......

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