Design and optimization of purine derivatives as in vivo active PDE10A inhibitors

Chen, L; Chen, DQ; Tang, L; Ren, J; Chen, JJ; Zhen, XC; Liu, YC; Zhang, CH; Luo, HB; Shen, JK; Xiong, B

Shen, JK; Xiong, B (reprint author), Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China.

BIOORGANIC & MEDICINAL CHEMISTRY, 2017; 25 (13): 3315

Abstract

Phosphodiesterases are important enzymes regulating signal transduction mediated by second messenger molecules cAMP or cGMP. PDE10A is a unique member......

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