Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction

Marshall, PR; Zhao, QY; Li, X; Wei, W; Periyakaruppiah, A; Zajaczkowski, EL; Leighton, LJ; Madugalle, SU; Basic, D; Wang, ZQ; Yin, JY; Liau, WS; Gupte, A; Walkley, CR; Bredy, TW

Bredy, TW (corresponding author), Univ Queensland, Queensland Brain Inst, Cognit Neuroepigenet Lab, Brisbane, Qld, Australia.

NATURE NEUROSCIENCE, 2020; 23 (6): 718

Abstract

Marshall et al. show that regions of the genome adopt a noncanonical Z-DNA state in the prefrontal cortex in response to fear learning and that bindin......

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