AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival

Cosimo, E; Tarafdar, A; Moles, MW; Holroyd, AK; Malik, N; Catherwood, MA; Hay, J; Dunn, KM; Macdonald, A; Guichard, S; O'Rourke, D; Leach, MT; Sansom, OJ; Cosulich, SC; McCaig, AM; Michie, AM

Michie, AM (reprint author), Univ Glasgow, Paul OGorman Leukaemia Res Ctr, Gartnavel Gen Hosp, 21 Shelley Rd, Glasgow G12 0ZD, Lanark, Scotland.

CLINICAL CANCER RESEARCH, 2019; 25 (5): 1574

Abstract

Purpose: To determine whether inhibition of mTORkinase-mediated signaling represents a valid therapeutic approach for chronic lymphocytic leukemia (CL......

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