Rationally targeted anti-VISTA antibody that blockades the C-C' loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner

Thakkar, D; Paliwal, S; Dharmadhikari, B; Guan, SY; Liu, LL; Kar, S; Tulsian, NK; Gruber, JJ; DiMascio, L; Paszkiewicz, KH; Ingram, PJ; Boyd-Kirkup, JD

Boyd-Kirkup, JD (通讯作者)，Natl Univ Singapore, Singapore, Singapore.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022; 10 (2):

Abstract

Background Despite significant progress in cancer immunotherapy in recent years, resistance to existing immune checkpoint therapies (ICT) is common. V......

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