Inhibition of Hsp90 Suppresses PI3K/AKT/mTOR Signaling and Has Antitumor Activity in Burkitt Lymphoma

Giulino-Roth, L; van Besien, HJ; Dalton, T; Totonchy, JE; Rodina, A; Taldone, T; Bolaender, A; Erdjument-Bromage, H; Sadek, J; Chadburn, A; Barth, MJ; Dela Cruz, FS; Rainey, A; Kung, AL; Chiosis, G; Cesarman, E

Giulino-Roth, L (reprint author), Weill Cornell Med Coll, 525 East 68th St,Payson 695, New York, NY 10065 USA.

MOLECULAR CANCER THERAPEUTICS, 2017; 16 (9): 1779

Abstract

Hsp90 is a molecular chaperone that protects proteins, including oncogenic signaling complexes, from proteolytic degradation. PU-H71 is a next-generat......

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