Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts

Berdiel-Acer, M; Maia, A; Hristova, Z; Borgoni, S; Vetter, M; Burmester, S; Becki, C; Michels, B; Abnaof, K; Binenbaum, I; Bethmann, D; Chatziioannou, A; Hasmann, M; Thomssen, C; Espinet, E; Wiemann, S

Berdiel-Acer, M; Wiemann, S (corresponding author), German Canc Res Ctr, Div Mol Genome Anal, Heidelberg, Germany.

ONCOGENE, ; ():

Abstract

HER3 is highly expressed in luminal breast cancer subtypes. Its activation by NRG1 promotes activation of AKT and ERK1/2, contributing to tumour progr......

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