Hypoxia-Activated Prodrugs of PERK Inhibitors

Liew, LP; Singleton, DC; Wong, WW; Cheng, GJ; Jamieson, SMF; Hay, MP

Hay, MP (reprint author), Univ Auckland, Auckland Canc Soc, Res Ctr, Sch Med Sci,Fac Med & Hlth Sci, Private Bag 92019, Auckland, New Zealand.; Hay, MP (reprint author), Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Symonds St, Auckland 1010, New Z

CHEMISTRY-AN ASIAN JOURNAL, 2019; 14 (8): 1238

Abstract

Tumour hypoxia plays an important role in tumour progression and resistance to therapy. Under hypoxia unfolded proteins accumulate in the endoplasmic ......

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