Radiolabeled Oligonucleotides Targeting the RNA Subunit of Telomerase Inhibit Telomerase and Induce DNA Damage in Telomerase-Positive Cancer Cells

Jackson, MR; Bavelaar, BM; Waghorn, PA; Gill, MR; El-Sagheer, AH; Brown, T; Tarsounas, M; Vallis, KA

Vallis, KA (reprint author), Univ Oxford, Oxford Inst Radiat Oncol, Old Rd Campus Res Bldg,Roosevelt Dr, Oxford OX3 7DQ, England.

CANCER RESEARCH, 2019; 79 (18): 4627

Abstract

Telomerase is expressed in the majority (>85%) of tumors, but has restricted expression in normal tissues. Long-term telomerase inhibition in malig......

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