Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death

Lee, S; Hoyt, S; Wu, XY; Garvie, C; McGaunn, J; Shekhar, M; Tötzl, M; Rees, MG; Cherniack, AD; Meyerson, M; Greulich, H

Greulich, H (通讯作者)，Broad Inst, Canc Program, Cambridge, MA 02142 USA.;Greulich, H (通讯作者)，Dana Farber Canc Inst, Boston, MA 02115 USA.

NATURE CHEMICAL BIOLOGY, 2023; 19 (3): 301

Abstract

Velcrin compounds kill cancer cells expressing high levels of phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12) by inducing complex ......

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