MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter: In vitro and in vivo study

Wu, ZX; Teng, QX; Yang, YQ; Acharekar, N; Wang, JQ; He, M; Yoganathan, S; Lin, J; Wang, J; Chen, ZS

Chen, ZS (通讯作者)，St Johns Univ, Dept Pharmaceut Sci, Coll Pharm & Hlth Sci, Queens, NY 11439 USA.;Wang, J (通讯作者)，Nantong Univ, Jiangyin Peoples Hosp, Dept Radiotherapy, Jiangyin 214400, Peoples R China.

ACTA PHARMACEUTICA SINICA B, 2022; 12 (5): 2609

Abstract

Overexpression of ABCG2 transporter in cancer cells has been linked to the development of multidrug resistance (MDR), an obstacle to cancer therapy. O......

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