Crystal structure and functional implication of a bacterial cyclic AMP-AMP-GMP synthetase

Ko, TP; Wang, YC; Tsai, CL; Yang, CS; Hou, MH; Chen, Y

Chen, Y (corresponding author), China Med Univ, Inst New Drug Dev, Taichung 406, Taiwan.; Chen, Y (corresponding author), China Med Univ, Res Ctr Canc Biol, Taichung 406, Taiwan.; Chen, Y (corresponding author), China Med Univ, New Drug Dev Ctr, Taichung 406, Taiwan.

NUCLEIC ACIDS RESEARCH, 2021; 49 (8): 4725

Abstract

Mammalian cyclic GMP-AMP synthase (cGAS) and its homologue dinucleotide cyclase in Vibrio cholerae (VcDncV) produce cyclic dinucleotides (CDNs) that p......

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