Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases

Takani, D; Takahashi, M; Hosokawa, M

Takahashi, M (通讯作者)，Chiba Inst Sci, Fac Pharm, 15-8,Shiomi-cho, Choshi, Chiba 2880025, Japan.

XENOBIOTICA, 2023; ():

Abstract

1. Carboxylesterase (CES) has been studied extensively, mostly with substrates in the monoester structures. We investigated the relationship between i......

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