PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production

Suzuki, T; Suzuki, Y; Hihara, T; Kubara, K; Kondo, K; Hyodo, K; Yamazaki, K; Ishida, T; Ishihara, H

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020; 588 ():

Abstract

PEGylation-modification with polyethylene glycol (PEG)-is useful for stabilizing lipid nanoparticles (LNPs). However, such PEGylation can prevent smal......

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