A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

Barghout, SH; Aman, A; Nouri, K; Blatman, Z; Arevalo, K; Thomas, GE; MacLean, N; Hurren, R; Ketela, T; Saini, M; Abohawya, M; Kiyota, T; Al-Awar, R; Schimmer, AD

Schimmer, AD (corresponding author), Princess Margaret Canc Res Tower,Room 8-706, Toronto, ON M5G 1L7, Canada.

JCI INSIGHT, 2021; 6 (5):

Abstract

TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiqui......

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