Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+T cell responses and impair oral vaccine efficacy

Bhattacharjee, A; Burr, AHP; Overacre-Delgoffe, AE; Tometich, JT; Yang, DY; Huckestein, BR; Linehan, JL; Spencer, SP; Hall, JA; Harrison, OJ; da Fonseca, DM; Norton, EB; Belkaid, Y; Hand, TW

Hand, TW (corresponding author), Univ Pittsburgh, UPMC Childrens Hosp Pittsburgh, RK Mellon Inst Pediat Res, Pediat Dept, Pittsburgh, PA 15224 USA.; Hand, TW (corresponding author), Univ Pittsburgh, Sch Med, Dept Immunol, Program Microbiol & Immunol, Pittsburgh, PA 15261 USA.

IMMUNITY, 2021; 54 (8): 1745

Abstract

Environmental enteric dysfunction (EED) is a gastrointestinal inflammatory disease caused by malnutrition and chronic infection. EED is associated wit......

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