Preclinical Evaluation and Nonhuman Primate Receptor Occupancy Study of F-18-JNJ-64413739, a PET Radioligand for P2X7 Receptors

Kolb, HC; Barrett, O; Bhattacharya, A; Chen, G; Constantinescu, C; Huang, CF; Letavic, M; Tamagnan, G; Xia, CFA; Zhang, W; Szardenings, AK

Szardenings, AK (reprint author), Janssen Res & Dev LLC, 3210 Merryfield Row, San Diego, CA 92121 USA.

JOURNAL OF NUCLEAR MEDICINE, 2019; 60 (8): 1154

Abstract

The P2X7 receptor is an adenosine triphosphate-gated ion channel, which is abundantly expressed in glial cells within the central nervous system and i......

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