Dabrafenib inhibits the growth of BRAF-WT cancers through CDK16 and NEK9 inhibition

Phadke, M; Rix, LLR; Smalley, I; Bryant, AT; Luo, YT; Lawrence, HR; Schaible, BJ; Chen, YA; Rix, U; Smalley, KSM

Smalley, KSM (reprint author), Moffit Canc Ctr & Res Inst, Dept Tumor Biol, 12902 Magnolia Dr, Tampa, FL 33612 USA.; Rix, U (reprint author), Moffit Canc Ctr & Res Inst, Dept Drug Discovery, 12902 Magnolia Dr, Tampa, FL 33612 USA.

MOLECULAR ONCOLOGY, 2018; 12 (1): 74

Abstract

Although the BRAF inhibitors dabrafenib and vemurafenib have both proven successful against BRAF-mutant melanoma, there seem to be differences in thei......

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