PTEN deficiency sensitizes endometrioid endometrial cancer to compound PARP-PI3K inhibition but not PARP inhibition as monotherapy

Bian, X; Gao, J; Luo, F; Rui, C; Zheng, T; Wang, D; Wang, Y; Roberts, TM; Liu, P; Zhao, JJ; Cheng, H

Zhao, JJ (reprint author), Dana Farber Canc Inst, Dept Canc Biol, 450 Brookline Ave Smith 936, Boston, MA 02215 USA.; Cheng, H (reprint author), Dalian Med Univ, Inst Canc, Hosp 2, Dalian 116023, Peoples R China.; Liu, P (reprint author), Dalian Med Univ,

ONCOGENE, 2018; 37 (3): 341

Abstract

Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as promising cancer therapeutics especially for tumors with deficient homologous recombina......

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