The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice

Dekeryte, R; Franklin, Z; Hull, C; Croce, L; Kamli-Salino, S; Helk, O; Hoffmann, PA; Yang, ZX; Riedel, G; Delibegovic, M; Platt, B

Delibegovic, M; Platt, B (corresponding author), Univ Aberdeen, Inst Med Sci, Foresterhill Hlth Campus, Aberdeen AB25 2ZD, Scotland.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2021; 1867 (7):

Abstract

Aim: The beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) has been identified as the central initiator of amyloid beta (A beta) gen......

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