Inhibition of HBV Expression in HBV Transgenic Mice Using AAV-Delivered CRISPR-SaCas9

Li, H; Sheng, CY; Liu, HB; Wang, S; Zhao, JY; Yang, L; Jia, LL; Li, P; Wang, LG; Xie, J; Xu, DP; Sun, YS; Qiu, SF; Song, HB

Qiu, SF; Song, HB (reprint author), Acad Mil Med Sci, Inst Dis Control & Prevent, Beijing, Peoples R China.; Sun, YS (reprint author), Acad Mil Med Sci, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China.

FRONTIERS IN IMMUNOLOGY, 2018; 9 ():

Abstract

The chronic production of hepatitis B viral (HBV) antigens could cause inflammation and necrosis, leading to elevation of liver enzymes from necrotic ......

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