Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase

Heyder, L; Hochban, PMM; Taylor, C; Chevillard, F; Siefker, C; Iking, C; Borchardt, H; Aigner, A; Klebe, G; Heine, A; Kolb, P; Diederich, WE

Diederich, WE (通讯作者),Philipps Univ Marburg, Inst Pharmazeut Chem, Zent Tumor & Immunbiol, Hans Meerwein Str 3, D-35032 Marburg, Germany.;Kolb, P (通讯作者),Philipps Univ Marburg, Inst Pharmazeut Chem, Marbacher Weg 6, D-35037 Marburg, Germany.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023; 245 ():

Abstract

In this study, fragment-sized hits binding to Pim-1 kinase with initially modest affinity were further optimized by combining computational, synthetic......

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