Inhibition of SMAD3 effectively reduces ADAMTS-5 expression in the early stages of osteoarthritis

Xiang, W; Wang, C; Zhu, ZJ; Wang, D; Qiu, ZY; Wang, WS

Wang, WS (通讯作者)，Shihezi Univ, Affiliated Hosp 1, Dept Orthoped Ctr, Sch Med, 107 North Second Rd, Shihezi 832000, Xinjiang, Peoples R China.;Wang, WS (通讯作者)，Shihezi Univ, Sch Med, Xinjiang, Peoples R China.

BMC MUSCULOSKELETAL DISORDERS, 2023; 24 (1):

Abstract

ObjectiveAs one of the most important protein-degrading enzymes, ADAMTS-5 plays an important role in the regulation of cartilage homeostasis, while mi......

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