Beyond growth signaling: Paneth cells metabolically support ISCs

Dayton, TL; Clevers, H

Clevers, H (reprint author), Royal Acad Arts & Sci KNAW, Hubrecht Inst, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands.; Clevers, H (reprint author), Univ Med Ctr Utrecht, Uppsalalaan 8, NL-3584 CT Utrecht, Netherlands.

CELL RESEARCH, 2017; 27 (7): 851

Abstract

Single Lgr5(+) intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures tha......

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