Rational design of stapled helical peptides as antidiabetic PPAR gamma antagonists to target coactivator site by decreasing unfavorable entropy penalty instead of increasing favorable enthalpy contribution

Zhang, Y; Wang, J; Li, WC; Guo, Y

Guo, Y (通讯作者)，Weifang Med Univ, Dept Endocrinol, Affiliated Hosp, Weifang 261041, Peoples R China.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2022; 51 (7-8): 535

Abstract

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a ligand-activated transcription factor belonging to the nuclear hormone receptor and......

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