2-Propylphenol Allosterically Modulates COQ8A to Enhance ATPase Activity

Murray, NH; Lewis, A; Pabon, JPR; Gross, ML; Henzler-Wildman, K; Pagliarini, DJ

Pagliarini, DJ (通讯作者)，Univ Wisconsin Madison, Dept Biochem, Madison, WI 53706 USA.;Pagliarini, DJ (通讯作者)，Morgridge Inst Res, Madison, WI 53715 USA.;Pagliarini, DJ (通讯作者)，Washington Univ, Dept Cell Biol & Physiol, Dept Biochem & Mol Biophys, Sch Med, St. Louis, MO 63110 USA.;Pagliarini, DJ (通讯作者)，Washington Univ, Dept Genet, Sch Med, St. Louis, MO 63110 USA.

ACS CHEMICAL BIOLOGY, 2022; 17 (8): 2031

Abstract

COQ8A is an atypical kinase-like protein that aids the biosynthesis of coenzyme Q, an essential cellular cofactor and antioxidant. COQ8A's mode of act......

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