Fc gamma RIIB-I232T polymorphic change allosterically suppresses ligand binding

Hu, W; Zhang, Y; Sun, XL; Zhang, TT; Xu, LL; Xie, HY; Li, ZG; Liu, WL; Lou, JZ; Chen, W

Chen, W (reprint author), Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurobiol, Hangzhou, Zhejiang, Peoples R China.; Chen, W (reprint author), Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Cardiol, Hangzhou, Zhejiang, Peoples R China.; Lou, JZ (re

ELIFE, 2019; 8 ():

Abstract

Fc gamma RIIB binding to its ligand suppresses immune cell activation. A single-nucleotide polymorphic (SNP) change, I232T, in the transmembrane (TM) ......

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