EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis

Zhang, XD; Chen, CP; Ling, CX; Luo, SH; Xiong, ZY; Liu, XL; Liao, CX; Xie, PY; Liu, YT; Zhang, LQ; Chen, ZH; Liu, ZF; Tang, J

Tang, J (通讯作者)，Guangdong Med Univ, Dept Anesthesiol, Affiliated Hosp, Zhanjiang 524000, Guangdong, Peoples R China.;Liu, ZF (通讯作者)，Gen Hosp Southern Theater Command PLA, Dept Crit Care Med, Guangzhou 510010, Guangdong, Peoples R China.

CELL DEATH & DISEASE, 2022; 13 (11):

Abstract

EGFR phosphorylation is required for TLR4-mediated macrophage activation during sepsis. However, whether and how intracellular EGFR is transported dur......

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