Novel human liver-tropic AAV variants define transferable domains that markedly enhance the human tropism of AAV7 and AAV8

Cabanes-Creus, M; Navarro, RG; Zhu, EH; Baltazar, G; Liao, SHY; Drouyer, M; Amaya, AK; Scott, S; Nguyen, LH; Westhaus, A; Hebben, M; Wilson, LOW; Thrasher, AJ; Alexander, IE; Lisowski, L

Lisowski, L (通讯作者)，Univ Sydney, Childrens Med Res Inst, Translat Vectorol Res Unit, Westmead, NSW 2145, Australia.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2022; 24 (): 88

Abstract

Recent clinical successes have intensified interest in using adeno-associated virus (AAV) vectors for therapeutic gene delivery. The liver is a key cl......

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