Empagliflozin Improves Insulin Sensitivity of the Hypothalamus in Humans With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial

Kullmann, S; Hummel, J; Wagner, R; Dannecker, C; Vosseler, A; Fritsche, L; Veit, R; Kantartzis, K; Machann, J; Birkenfeld, AL; Stefan, N; Haring, HU; Peter, A; Preissl, H; Fritsche, A; Heni, M

Heni, M (通讯作者)，Univ Tubingen, Inst Diabet Res & Metab Dis, Helmholtz Ctr Munich, Tubingen, Germany.;Heni, M (通讯作者)，German Ctr Diabet Res, Neuherberg, Germany.;Heni, M (通讯作者)，Eberhard Karls Univ Tubingen, Dept Internal Med, Div Diabetol Endocrinol & Nephrol, Tubingen, Germany.;Heni, M (通讯作者)，Eberhard Karls Univ Tubingen, Inst Clin Chem & Pathobiochem, Dept Diagnost Lab Med, Tubingen, Germany.

DIABETES CARE, 2022; 45 (2): 398

Abstract

OBJECTIVE Insulin action in the human brain reduces food intake, improves whole-body insulin sensitivity, and modulates body fat mass and its distribu......

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