Blocking CD38-driven fratricide among T cells enables effective antitumor activity by CD38-specific chimeric antigen receptor T cells

Gao, ZT; Tong, C; Wang, Y; Chen, DY; Wu, ZQ; Han, WD

Wu, ZQ; Han, WD (reprint author), Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Sch Life Sci, Dept Mol Biol,Inst Basic Med, Beijing 100086, Peoples R China.

JOURNAL OF GENETICS AND GENOMICS, 2019; 46 (8): 367

Abstract

Chimeric antigen receptor T-cell (CAR T) therapy is a kind of effective cancer immunotherapy. However, designing CARs remains a challenge because many......

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