Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation

Cosin-Roger, J; Spalinger, MR; Ruiz, PA; Stanzel, C; Terhalle, A; Wolfram, L; Melhem, H; Atrott, K; Lang, S; Frey-Wagner, I; Fried, M; Scharl, M; Hausmann, M; Rogler, G

Rogler, G (reprint author), Univ Zurich, Univ Hosp Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.

PLOS ONE, 2018; 13 (2):

Abstract

Gp96 is an endoplasmic reticulum chaperone for multiple protein substrates. Its lack in intestinal macrophages of Crohn's disease (CD) patients is cor......

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