The Biodistribution of a CD3 and EpCAM Bispecific T-Cell Engager Is Driven by the CD3 Arm

Suurs, FV; Lorenczewski, G; Stienen, S; Friedrich, M; de Vries, EGE; de Groot, DJA; Lub-de Hooge, MN

Lub-de Hooge, MN (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, POB 30-001, NL-9700 RB Groningen, Netherlands.

JOURNAL OF NUCLEAR MEDICINE, 2020; 61 (11): 1594

Abstract

Bispecific T-cell engager (BiTE) molecules are designed to engage and activate cytotoxic T cells to kill tumor cells. Little is known about their biod......

Full Text Link