Systematic Investigation of the Permeability of Androgen Receptor PROTACs

Scott, DE; Rooney, TPC; Bayle, ED; Mirza, T; Willems, HMG; Clarke, JH; Andrews, SP; Skidmore, J

Skidmore, J (corresponding author), Univ Cambridge, ALBORADA Drug Discovery Inst, Cambridge CB2 0AH, England.

ACS MEDICINAL CHEMISTRY LETTERS, 2020; 11 (8): 1539

Abstract

Bifunctional molecules known as PROTACs simultaneously bind an E3 ligase and a protein of interest to direct ubiquitination and clearance of that prot......

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