Development of a Robust Scale-Up Synthetic Route for BPR1K871: A Clinical Candidate for the Treatment of Acute Myeloid Leukemia and Solid Tumors

Reddy, JS; Chen, CM; Coumar, MS; Sun, HY; Sun, N; Hsieh, HP

Hsieh, HP (corresponding author), Natl Hlth Res Inst, Inst Biotechnol & Pharmaceut Res, Zhunan 35053, Taiwan.; Hsieh, HP (corresponding author), Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan.; Hsieh, HP (corresponding author), Acad Sinica, Biomed Translat Res Ctr, Taipei 11520, Taiwan.

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021; 25 (4): 817

Abstract

Herein, a robust and scalable procedure for the synthesis of multikinase inhibitor BPR1K871 (1, a quinazoline compound bearing a substituted thiazolin......

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