Combination of p38 MAPK inhibitor with PD-L1 antibody effectively prolongs survivals of temozolomide-resistant glioma-bearing mice via reduction of infiltrating glioma-associated macrophages and PD-L1 expression on resident glioma-associated microglia

Dang, WQ; Xiao, JF; Ma, QH; Miao, JY; Cao, MF; Chen, L; Shi, Y; Yao, XH; Yu, SC; Liu, XD; Cui, YH; Zhang, X; Bian, XW

Zhang, X; Bian, XW (corresponding author), Third Mil Med Univ, Southwest Hosp, Inst Pathol, Army Med Univ, Chongqing 400038, Peoples R China.; Zhang, X; Bian, XW (corresponding author), Third Mil Med Univ, Southwest Hosp, Southwest Canc Ctr, Army Med Univ, Chongqing 400038, Peoples R China.; Zhang, X; Bian, XW (corresponding author), Minist Educ China, Key Lab Tumor Immunopathol, Chongqing 400038, Peoples R China.

BRAIN TUMOR PATHOLOGY, 2021; 38 (3): 189

Abstract

Current conventional treatment strategies for glioblastoma (GBM) have limited efficacy due to the rapid development of resistance to temozolomide (TMZ......

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