Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine O-acyltransferase or Wnt secretion

Rao, DM; Shackleford, MT; Bordeaux, EK; Sottnik, JL; Ferguson, RL; Yamamoto, TM; Wellberg, EA; Bitler, BG; Sikora, MJ

Sikora, MJ (reprint author), Mail Stop 8104,Res Complex 1 South,Rm 5117, Aurora, CO 80045 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2019; 294 (52): 19950

Abstract

Porcupine O-acyltransferase (PORCN) is considered essential for Wnt secretion and signaling. However, we observed that PORCN inhibition does not pheno......

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