Mitochondrial DNA variation and cancer

Kopinski, PK; Singh, LN; Zhang, SP; Lott, MT; Wallace, DC

Wallace, DC (corresponding author), Childrens Hosp Philadelphia, Ctr Mitochondrial & Epigen Med, Philadelphia, PA 19104 USA.; Wallace, DC (corresponding author), Univ Penn, Dept Pediat, Div Human Genet, Perelman Sch Med, Philadelphia, PA 19104 USA.

NATURE REVIEWS CANCER, 2021; 21 (7): 431

Abstract

Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two classes of cancer mtDNA variants can be identified: de novo muta......

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