The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity

Ricketts, MD; Emptage, RP; Blobel, GA; Marmorstein, R

Marmorstein, R (通讯作者)，Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA.;Marmorstein, R (通讯作者)，Univ Penn, Abramson Family Canc Res Inst, Perelman Sch Med, Philadelphia, PA 19104 USA.

JOURNAL OF BIOLOGICAL CHEMISTRY, 2022; 298 (10):

Abstract

The heme-regulated inhibitor (HRI) is a heme-sensing kinase that regulates mRNA translation in erythroid cells. In heme deficiency, HRI is activated t......

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