CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry

Van Hout, A; Klarenbeek, A; Bobkov, V; Doijen, J; Arimont, M; Zhao, CX; Heukers, R; Rimkunas, R; de Graaf, C; Verrips, T; van der Woning, B; de Haard, H; Rucker, JB; Vermeire, K; Handel, T; Van Loy, T; Smit, MJ; Schols, D

Schols, D (reprint author), Katholieke Univ Leuven, Rega Inst, Lab Virol & Chemotherapy, Dept Microbiol & Immunol, Herestr 49, B-3000 Leuven, Belgium.

BIOCHEMICAL PHARMACOLOGY, 2018; 158 (): 402

Abstract

The chemokine receptor CXCR4 and its ligand CXCL12 contribute to a variety of human diseases, such as cancer. CXCR4 is also a major co-receptor facili......

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