Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists

Butera, R; Wazynska, M; Magiera-Mularz, K; Plewka, J; Musielak, B; Surmiak, E; Sala, D; Kitel, R; de Bruyn, M; Nijman, HW; Elsinga, PH; Holak, TA; Domling, A

Domling, A (corresponding author), Univ Groningen, Dept Drug Design, NL-9713 AV Groningen, Netherlands.

ACS MEDICINAL CHEMISTRY LETTERS, 2021; 12 (5): 768

Abstract

The PD-1/PD-L1 axis has proven to be a highly efficacious target for cancer immune checkpoint therapy with several approved antibodies. Also, small mo......

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